PEG-covered lipid surfaces: bilayers and monolayers.


Journal Article

In this review paper we survey the ways in which various micropipet techniques have been used to study the mechanochemical and interactive features of lipid bilayer vesicles and monolayer-coated gas bubbles. Special emphasis will be made on characterizing the barrier properties of grafted PEG layers and how a hierarchical approach that uses a short barrier and extended ligand allows us to start to mimic nature's own solution to the problem of ubiquitous repulsion and specific attraction. The information gained from such studies not only characterizes the membrane and other lipid surfaces and their intersurface interactions from a fundamental materials science perspective, but also provides essential materials property data that are required for the successful design and deployment of lipid-based carriers and other capsules in applications involving this so-called 'stealthy' surface.

Full Text

Duke Authors

Cited Authors

  • Needham, D; Kim, DH

Published Date

  • October 2000

Published In

Volume / Issue

  • 18 / 3-4

Start / End Page

  • 183 - 195

PubMed ID

  • 10915943

Pubmed Central ID

  • 10915943

Electronic International Standard Serial Number (EISSN)

  • 1873-4367

International Standard Serial Number (ISSN)

  • 0927-7765

Digital Object Identifier (DOI)

  • 10.1016/s0927-7765(99)00147-2


  • eng