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Misoprostol Modulation of Dendritic Cell Function in Immune Responses.

Publication ,  Journal Article
Everson, MP; Lagoo, A; McDuffie, DS; Pillion, DJ
Published in: Am J Ther
September 1995

Dendritic cells (DC) from blood and other tissues are potent accessory cells for primary immune responses. Because prostaglandins from monocytes and macrophages can suppress DC and T-cell function, we sought to investigate the binding properties of misoprostol (MPL), a prostaglandin E(1) analog, and its regulation of DC function. Results of mouse and human experiments have suggested 1) that MPL could significantly inhibit DC-induced T-cell proliferation in oxidative mitogenesis and allogeneic mixed leukocyte reactions by decreasing interleukin-2 production in DC-T cell cocultures, and 2) that MPL could bind to human peripheral blood mononuclear cells via specific high-affinity MPL binding sites as well as through nonspecific MPL uptake. Taken together, these data suggest that MPL can bind high-affinity and/or nonspecific cell surface receptors and subsequently regulate T-cell growth and cytokine production such as that induced by DC and associated with primary immune responses.

Duke Scholars

Published In

Am J Ther

DOI

EISSN

1536-3686

Publication Date

September 1995

Volume

2

Issue

9

Start / End Page

626 / 629

Location

United States

Related Subject Headings

  • Cardiovascular System & Hematology
  • 1117 Public Health and Health Services
 

Citation

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Everson, M. P., Lagoo, A., McDuffie, D. S., & Pillion, D. J. (1995). Misoprostol Modulation of Dendritic Cell Function in Immune Responses. Am J Ther, 2(9), 626–629. https://doi.org/10.1097/00045391-199509000-00009
Everson, Michael P., Anand Lagoo, Deborrah S. McDuffie, and Dennis J. Pillion. “Misoprostol Modulation of Dendritic Cell Function in Immune Responses.Am J Ther 2, no. 9 (September 1995): 626–29. https://doi.org/10.1097/00045391-199509000-00009.
Everson MP, Lagoo A, McDuffie DS, Pillion DJ. Misoprostol Modulation of Dendritic Cell Function in Immune Responses. Am J Ther. 1995 Sep;2(9):626–9.
Everson, Michael P., et al. “Misoprostol Modulation of Dendritic Cell Function in Immune Responses.Am J Ther, vol. 2, no. 9, Sept. 1995, pp. 626–29. Pubmed, doi:10.1097/00045391-199509000-00009.
Everson MP, Lagoo A, McDuffie DS, Pillion DJ. Misoprostol Modulation of Dendritic Cell Function in Immune Responses. Am J Ther. 1995 Sep;2(9):626–629.

Published In

Am J Ther

DOI

EISSN

1536-3686

Publication Date

September 1995

Volume

2

Issue

9

Start / End Page

626 / 629

Location

United States

Related Subject Headings

  • Cardiovascular System & Hematology
  • 1117 Public Health and Health Services