In vitro interactions between DMSA-coated maghemite nanoparticles and human fibroblasts: A physicochemical and cyto-genotoxical study.

Journal Article (Journal Article)

Although the current production of oxide nanoparticles may be modest, the wide range of proposed applications and forecasted growth in production has raised questions about the potential impact of these nanoparticles on the environment and human health. Iron oxide nanoparticles have been proposed for an increasing number of biomedical applications although in vitro toxicity depending on the particles coating has been evidenced. The aim of this study was to examine the potential in vitro cyto- and genotoxicity on human dermal fibroblasts of DMSA-coated maghemite nanoparticles (NmDMSA) as a function of well-defined physicochemical states. Well-stabilized NmDMSA produced weak cytotoxic and no genotoxic effects. This is attributed in part to the DMSA coating, which serves as a barrier for a direct contact between nano-oxide and fibroblasts, inhibiting a potential toxic effect.

Full Text

Duke Authors

Cited Authors

  • Auffan, M; Decome, L; Rose, J; Orsiere, T; De Meo, M; Briois, V; Chaneac, C; Olivi, L; Berge-Lefranc, J-L; Botta, A; Wiesner, MR; Bottero, J-Y

Published Date

  • July 2006

Published In

Volume / Issue

  • 40 / 14

Start / End Page

  • 4367 - 4373

PubMed ID

  • 16903272

Electronic International Standard Serial Number (EISSN)

  • 1520-5851

International Standard Serial Number (ISSN)

  • 0013-936X

Digital Object Identifier (DOI)

  • 10.1021/es060691k


  • eng