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Deformation and flow of neutrophils and monocytes

Publication ,  Journal Article
Hochmuth, RM; Needham, D; Ting-Beall, HP
Published in: American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
December 1, 1991

The deformation and flow of neutrophils and monocytes in the smallest vessels is studied experimentally. The preparation of cells, micropipet manipulation, measurement of cortical tension, measurement of viscosity and of the rate of recovery is described. It is concluded that neutrophils and monocytes behave more like a liquid than a solid. However. it is a simplification to say that these cells behave like a Newtonian liquid drop with a constant cortical tension. The cell's complex cytoplasmic fluid has a distionctly non-Newtonian character. It responds elastically when deformed rapidly, but its elastic memory fades quickly - in less than 5 seconds. The behavior of the neutrophil as a Maxwell liquid may account for its shear-thinning behavior. The cortical tension also may change as the cell is deformed.

Duke Scholars

Published In

American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

Publication Date

December 1, 1991

Volume

20

Start / End Page

417 / 419

Related Subject Headings

  • Biomedical Engineering
 

Citation

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Hochmuth, R. M., Needham, D., & Ting-Beall, H. P. (1991). Deformation and flow of neutrophils and monocytes. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, 20, 417–419.
Hochmuth, R. M., D. Needham, and H. P. Ting-Beall. “Deformation and flow of neutrophils and monocytes.” American Society of Mechanical Engineers, Bioengineering Division (Publication) BED 20 (December 1, 1991): 417–19.
Hochmuth RM, Needham D, Ting-Beall HP. Deformation and flow of neutrophils and monocytes. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 1991 Dec 1;20:417–9.
Hochmuth, R. M., et al. “Deformation and flow of neutrophils and monocytes.” American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, vol. 20, Dec. 1991, pp. 417–19.
Hochmuth RM, Needham D, Ting-Beall HP. Deformation and flow of neutrophils and monocytes. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 1991 Dec 1;20:417–419.

Published In

American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

Publication Date

December 1, 1991

Volume

20

Start / End Page

417 / 419

Related Subject Headings

  • Biomedical Engineering