The micromechanical environment of intervertebral disc cells: effect of matrix anisotropy and cell geometry predicted by a linear model.

Cells of the intervertebral disc exhibit spatial variations in phenotype and morphology that may be related to differences in their local mechanical environments. In this study, the stresses, strains, and dilatations in and around cells of the intervertebral disc were studied with an analytical model of the cell as a mechanical inclusion embedded in a transversely isotropic matrix. In response to tensile loading of the matrix, the local mechanical environment of the cell differed among the anatomic regions of the disc and was strongly influenced by changes in both matrix anisotropy and parameters of cell geometry. The results of this study suggest that the local cellular mechanical environment may play a role in determining both cell morphology in situ and the inhomogeneous response to mechanical loading observed in cells of the disc.

Duke Authors

Cited Authors

  • Baer, AE; Setton, LA

Published Date

  • June 2000

Published In

Volume / Issue

  • 122 / 3

Start / End Page

  • 245 - 251

PubMed ID

  • 10923292

International Standard Serial Number (ISSN)

  • 0148-0731

Language

  • eng

Citation Source

  • PubMed