Mechanical properties of matrix synthesized by intervertebral disc cells in an alginate culture system

The mechanical function of matrix synthesized by intervertebral disc (IVD) cells in alginate was examined by measuring material properties in both compression and shear testing of configurations. Samples were evaluated for mechanical function after 1, 4, 8, and 16 weeks in culture. The main results is that while IVD cells exhibit significant biosynthetic activity at both transcriptional and translational stages when cultured in alginate, they are not able to form a functional matrix.

Duke Authors

Cited Authors

  • Baer, AE; Wang, JY; Setton, LA

Published Date

  • 1999

Published In

  • American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

Volume / Issue

  • 42 /

Start / End Page

  • 119 - 120

Citation Source

  • SciVal