Altered mechanics of tibial cartilage following joint immobilization in a canine model

To study the effect of immobilization, the compressive and shear properties of articular cartilage were quantified at sites corresponding to those of elevated MMP staining on the tibial plateau of mongrel dogs. Cartilage samples were tested in compression and torsion on a displacement-controlled rheometer. The samples were weighed after testing and again after lyophilization to determine water content as the percentage of tissue wet weight. The results support the hypothesis that knee joint immobilization will produce deleterious changes in cartilage function at the tibial plateau.

Duke Authors

Cited Authors

  • Setton, LA; Perry, CH; LeRoux, MA; Wang, JY; Howell, DS; Cheung, HS

Published Date

  • 1999

Published In

  • American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

Volume / Issue

  • 42 /

Start / End Page

  • 71 - 72

Citation Source

  • SciVal