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Learning and recall in subjects at genetic risk for Alzheimer's disease.

Publication ,  Journal Article
Chen, JG; Edwards, CL; Vidyarthi, S; Pitchumoni, S; Tabrizi, S; Barboriak, D; Charles, HC; Doraiswamy, PM
Published in: J Neuropsychiatry Clin Neurosci
2002

Deficits in delayed recall of learned information may be an early marker of Alzheimer's disease (AD). The apolipoprotein E E4 allele and a positive family history (FH) are both genetic risk factors for AD. The authors cross-sectionally compared performance on the California Verbal Learning Test (CVLT) in 153 prospectively recruited normal elderly subjects (mean age 67 years, mean MMSE=28) stratified by genetic risk into four groups (E4+/FH+, E4+/FH-, E4-/FH+, E4-/FH-). Neither FH nor E4 status affected performance, except on List B (a distraction word list), on which the FH+ group performed worse. The high-risk group (E4+/FH+) also performed worse on List B than the low-risk group (E4-/FH-) but did not differ on other measures. Memory impairments associated with genetic or family history risk may not manifest until the person is much closer to the onset age of AD.

Duke Scholars

Published In

J Neuropsychiatry Clin Neurosci

DOI

ISSN

0895-0172

Publication Date

2002

Volume

14

Issue

1

Start / End Page

58 / 63

Location

United States

Related Subject Headings

  • Verbal Learning
  • Risk Factors
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Neuropsychological Tests
  • Middle Aged
  • Mental Recall
  • Male
  • Humans
  • Female
 

Citation

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MLA
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Chen, J. G., Edwards, C. L., Vidyarthi, S., Pitchumoni, S., Tabrizi, S., Barboriak, D., … Doraiswamy, P. M. (2002). Learning and recall in subjects at genetic risk for Alzheimer's disease. J Neuropsychiatry Clin Neurosci, 14(1), 58–63. https://doi.org/10.1176/jnp.14.1.58
Chen, J Gene, Christopher L. Edwards, Suman Vidyarthi, Suresh Pitchumoni, Sara Tabrizi, Dan Barboriak, H Cecil Charles, and P Murali Doraiswamy. “Learning and recall in subjects at genetic risk for Alzheimer's disease.J Neuropsychiatry Clin Neurosci 14, no. 1 (2002): 58–63. https://doi.org/10.1176/jnp.14.1.58.
Chen JG, Edwards CL, Vidyarthi S, Pitchumoni S, Tabrizi S, Barboriak D, et al. Learning and recall in subjects at genetic risk for Alzheimer's disease. J Neuropsychiatry Clin Neurosci. 2002;14(1):58–63.
Chen, J. Gene, et al. “Learning and recall in subjects at genetic risk for Alzheimer's disease.J Neuropsychiatry Clin Neurosci, vol. 14, no. 1, 2002, pp. 58–63. Pubmed, doi:10.1176/jnp.14.1.58.
Chen JG, Edwards CL, Vidyarthi S, Pitchumoni S, Tabrizi S, Barboriak D, Charles HC, Doraiswamy PM. Learning and recall in subjects at genetic risk for Alzheimer's disease. J Neuropsychiatry Clin Neurosci. 2002;14(1):58–63.
Journal cover image

Published In

J Neuropsychiatry Clin Neurosci

DOI

ISSN

0895-0172

Publication Date

2002

Volume

14

Issue

1

Start / End Page

58 / 63

Location

United States

Related Subject Headings

  • Verbal Learning
  • Risk Factors
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Neuropsychological Tests
  • Middle Aged
  • Mental Recall
  • Male
  • Humans
  • Female