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Propagation model using the DiFrancesco-Noble equations. Comparison to reported experimental results.

Publication ,  Journal Article
Cabo, C; Barr, RC
Published in: Medical & biological engineering & computing
May 1992

Propagation, re-entry and the effects of stimuli within the conduction system can be studied effectively with computer models when the pertinent membrane properties can be represented accurately in mathematical form. To date, no membrane models have been shown to be accurate representations during repolarisation and recovery of excitability, although for the Purkinje membrane the DiFrancesco-Noble (DN) model has become a possibility. The paper examines the DN model, restates its equations and compares simulated waveforms in a number of propagation contexts to experimental measurements reported in the literature. The objective is to determine whether or not the DN model reproduced phenomena such as supernormality, shortening in action potential duration during pacing rate increases, alternation of duration with changes in rhythm, graded responses and 'all-or-none' repolarisation in a quantitatively realistic way, as each of these come from time and space dependencies not directly a part of the ionic current measurements on which the DN model is based. The results show that the DN equations correctly simulate these situations and support the goal of having a model that is broadly applicable to Purkinje tissue, including refractory period properties and response to electrical stimulation.

Duke Scholars

Published In

Medical & biological engineering & computing

DOI

EISSN

1741-0444

ISSN

0140-0118

Publication Date

May 1992

Volume

30

Issue

3

Start / End Page

292 / 302

Related Subject Headings

  • Models, Neurological
  • Mathematics
  • Humans
  • Heart Conduction System
  • Cardiac Pacing, Artificial
  • Biomedical Engineering
  • Action Potentials
  • 4611 Machine learning
  • 4603 Computer vision and multimedia computation
  • 4003 Biomedical engineering
 

Citation

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Cabo, C., & Barr, R. C. (1992). Propagation model using the DiFrancesco-Noble equations. Comparison to reported experimental results. Medical & Biological Engineering & Computing, 30(3), 292–302. https://doi.org/10.1007/bf02446967
Cabo, C., and R. C. Barr. “Propagation model using the DiFrancesco-Noble equations. Comparison to reported experimental results.Medical & Biological Engineering & Computing 30, no. 3 (May 1992): 292–302. https://doi.org/10.1007/bf02446967.
Cabo C, Barr RC. Propagation model using the DiFrancesco-Noble equations. Comparison to reported experimental results. Medical & biological engineering & computing. 1992 May;30(3):292–302.
Cabo, C., and R. C. Barr. “Propagation model using the DiFrancesco-Noble equations. Comparison to reported experimental results.Medical & Biological Engineering & Computing, vol. 30, no. 3, May 1992, pp. 292–302. Epmc, doi:10.1007/bf02446967.
Cabo C, Barr RC. Propagation model using the DiFrancesco-Noble equations. Comparison to reported experimental results. Medical & biological engineering & computing. 1992 May;30(3):292–302.
Journal cover image

Published In

Medical & biological engineering & computing

DOI

EISSN

1741-0444

ISSN

0140-0118

Publication Date

May 1992

Volume

30

Issue

3

Start / End Page

292 / 302

Related Subject Headings

  • Models, Neurological
  • Mathematics
  • Humans
  • Heart Conduction System
  • Cardiac Pacing, Artificial
  • Biomedical Engineering
  • Action Potentials
  • 4611 Machine learning
  • 4603 Computer vision and multimedia computation
  • 4003 Biomedical engineering