Electric field stimulation of excitable tissue.

Journal Article

This paper examines the transmembrane voltage response of an unmyelinated fiber to a stimulating electric field from a point current source. For subthreshold conditions, analytic expressions for the transmembrane potential, vm, are developed that include the specific effects of fiber-source distance, h, and time from the onset of the stimulus, T. Suprathreshold effects are determined for two examples by extending the analytical results with a numerical model. The vm response is a complex evolution in time, especially for small h, that differs markedly from the "activating function." In general, the subthreshold response is a good predictor of the wave shape of the suprathreshold vm, but a poor predictor of its magnitude. The subthreshold response also is a good (but not a precise) predictor of the region where excitation begins.

Full Text

Duke Authors

Cited Authors

  • Plonsey, R; Barr, RC

Published Date

  • April 1995

Published In

Volume / Issue

  • 42 / 4

Start / End Page

  • 329 - 336

PubMed ID

  • 7729832

International Standard Serial Number (ISSN)

  • 0018-9294

Language

  • eng

Conference Location

  • United States