A focal stress gradient-dependent mass transfer mechanism for atherogenesis in branching arteries.

Journal Article (Journal Article)

A new arterial wall permeability function, based on the local wall shear stress gradient, has been developed and employed to simulate enhanced low density lipoprotein transfer across the endothelium. the atherosclerotic model used is that of the aorto-celiac junction of rabbits. The experimentally validated computer simulation model for convection mass transfer provides further evidence that the wall shear stress gradient is a reliable predictor of critical atherogenic sites in branching arteries. Some of the underlying biological aspects of atherogenesis due to locally significant and sustained wall shear stress gradient values are briefly discussed.

Full Text

Duke Authors

Cited Authors

  • Lei, M; Kleinstreuer, C; Truskey, GA

Published Date

  • June 1996

Published In

Volume / Issue

  • 18 / 4

Start / End Page

  • 326 - 332

PubMed ID

  • 8963477

Electronic International Standard Serial Number (EISSN)

  • 1873-4030

International Standard Serial Number (ISSN)

  • 1350-4533

Digital Object Identifier (DOI)

  • 10.1016/1350-4533(95)00045-3


  • eng