"Non-Fouling" Oligo(ethylene glycol)-Functionalized Polymer Brushes Synthesized by Surface-Initiated Atom Transfer Radical Polymerization


Journal Article

The synthesis of (EG) n-functionalized polymer brushes of tunable thicknesses in the 5-50 nm range by surface initiated polymerization was discussed. It was shown that these polymer brushes exhibited no detectable adsorption of proteins, and were cell resistant for up to a month under typical cell culture conditions. It was also shown that the synthesis method was compatible with a range of patterning techniques from the nano- to microscale, which enabled the patterning of cells in a biologically relevant milieu over extended period of time. These non-fouling surfaces and topographical structures were found to be useful as model quasi-three-dimensional systems to investigate the response of cells to chemical and topographical cues.

Full Text

Duke Authors

Cited Authors

  • Ma, H; Hyun, J; Stiller, P; Chilkoti, A

Published Date

  • February 17, 2004

Published In

Volume / Issue

  • 16 / 4

Start / End Page

  • 338 - 341

International Standard Serial Number (ISSN)

  • 0935-9648

Digital Object Identifier (DOI)

  • 10.1002/adma.200305830

Citation Source

  • Scopus