Quantification of the effects of chain length and concentration on the thermal behavior of elastin-like polypeptides.

Journal Article (Journal Article)

At a specific temperature, elastin-like polypeptides (ELPs) undergo a sharp solubility transition that can be exploited in a variety of applications in biotechnology and medicine. The temperature of the transition varies with ELP sequence, molecular weight, and concentration. We present a single equation of three parameters that quantitatively predicts the transition temperature as a function of ELP length and concentration for an ELP of a fixed composition. This model should be useful both for the design of new ELP sequences that exhibit a desired transition temperature and for the selection of variables to trigger the phase transition of an ELP for a given application.

Full Text

Duke Authors

Cited Authors

  • Meyer, DE; Chilkoti, A

Published Date

  • May 2004

Published In

Volume / Issue

  • 5 / 3

Start / End Page

  • 846 - 851

PubMed ID

  • 15132671

Electronic International Standard Serial Number (EISSN)

  • 1526-4602

International Standard Serial Number (ISSN)

  • 1525-7797

Digital Object Identifier (DOI)

  • 10.1021/bm034215n


  • eng