HEMODYNAMIC MEASUREMENTS IN HUMAN ARTERIAL CASTS: GEOMETRIC EFFECTS AND MORPHOLOGICAL CORRELATES.
The distribution of atherosclerotic lesions in the large arteries strongly suggests that blood flow patterns (hemodynamics) adjacent to the vessel wall play a role in the development of the disease. The authors' approach has been to make hemodynamic measurements near the walls of human arterial casts, and to compare the hemodynamics with the morphology of the arterial segment from which the cast was made. High spatial resolution and sufficient accuracy are obtained by using a laser Doppler velocimeter to make velocity measurements fractions of a millimeter from the wall, without disturbing the flow; this requires, of course, a transparent casting material and a fluid which matches it in refractive index. In contrast to electrochemical measurements, one can look at the flow field at any point in the cast, guided by as well as giving direction to, the morphological studies on the original vessel.
Friedman, MH; Bargeron, CB; Deters, OJ; Mark, FF; Hutchins, GM
American Society of Mechanical Engineers, Applied Mechanics Division, Amd
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