The motion of coronary arteries has attracted more and more attention because of its possible effects on the development of atherosclerosis and potential clinical application for diagnosis of cardiovascular disease. Angiography is the best clinical modality so far to extract this information spatially and temporally. In this paper, a new method, which combines "snakes" and a template matching technique, is proposed to track vessel segments in angiographic image sequences. By considering both global and local motion, the vessel can be tracked well in a cardiac cycle.