Sensitivity of temporal excitation properties to the neuronal element activated by extracellular stimulation.
Published
Journal Article
Measurements of the chronaxies and refractory periods with extracellular stimuli have been used to conclude that large diameter axons are responsible for the effects of deep brain stimulation (DBS). We hypothesized that because action potential initiation by extracellular stimulation occurs in the axons of central nervous system (CNS) neurons, the chronaxies and refractory periods determined using extracellular stimulation would be similar for cells and axons. Computer simulation was used to determine the sensitivity of chronaxie and refractory period to the neural element stimulated. The results demonstrate that chronaxies and refractory periods were dependent on the polarity of the extracellular stimulus and the electrode-to-neuron distance, and indicate that there is little systematic difference in either chronaxies or refractory periods between local cells or axons of passage with extracellular stimulation. This finding points out the difficulty in drawing conclusions regarding which neuronal elements are activated based on extracellular measurements of temporal excitation properties.
Full Text
Duke Authors
Cited Authors
- Miocinovic, S; Grill, WM
Published Date
- January 2004
Published In
Volume / Issue
- 132 / 1
Start / End Page
- 91 - 99
PubMed ID
- 14687678
Pubmed Central ID
- 14687678
Electronic International Standard Serial Number (EISSN)
- 1872-678X
International Standard Serial Number (ISSN)
- 0165-0270
Digital Object Identifier (DOI)
- 10.1016/j.jneumeth.2003.09.004
Language
- eng