Linear algebraic transformations of the bidomain equations: implications for numerical methods.
A mathematical framework is presented for the treatment of the bidomain equations used to model propagation in cardiac tissue. This framework is independent of the model used to represent membrane ionic currents and incorporates boundary conditions and other constraints. By representing the bidomain equations in the operator notation L phi = F, various algebraic transformations can be expressed as PLQ-1 psi = PF, where P and Q are linear operators. The authors show how previous work fits into this framework and discuss the implications of various transformation for numerical methods of solution. Although such transformations allow many choices of independent variable, these results emphasize the fundamental importance of the transmembrane potential.
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Related Subject Headings
- Models, Cardiovascular
- Mathematics
- Linear Models
- Humans
- Heart
- Electrophysiology
- Bioinformatics
- Animals
- 49 Mathematical sciences
- 31 Biological sciences
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Models, Cardiovascular
- Mathematics
- Linear Models
- Humans
- Heart
- Electrophysiology
- Bioinformatics
- Animals
- 49 Mathematical sciences
- 31 Biological sciences