Real-time in vivo color Doppler optical coherence tomography.

Published

Journal Article

Color Doppler optical coherence tomography (CDOCT) is a functional extension of optical coherence tomography (OCT) that can image flow in turbid media. We have developed a CDOCT system capable of imaging flow in real time. Doppler processing of the analog signal is accomplished in hardware in the time domain using a novel autocorrelation technique. This Doppler processing method is compatible with a high speed OCT system capable of imaging in real time. Using this system, we demonstrate cross-sectional imaging of bidirectional flow with CDOCT at four frames per second in a tissue-simulating phantom consisting of intralipid solution flowing in glass capillaries. As a demonstration of real-time imaging of blood flow in vivo we imaged pulsatible blood flow in a rat femoral artery at eight frames per second. Issues of velocity sensitivity, imaging speed, and range of velocity measurement are discussed, as well as potential applications of real-time CDOCT.

Full Text

Duke Authors

Cited Authors

  • Rollins, AM; Yazdanfar, S; Barton, JK; Izatt, JA

Published Date

  • January 2002

Published In

Volume / Issue

  • 7 / 1

Start / End Page

  • 123 - 129

PubMed ID

  • 11818020

Pubmed Central ID

  • 11818020

Electronic International Standard Serial Number (EISSN)

  • 1560-2281

International Standard Serial Number (ISSN)

  • 1083-3668

Digital Object Identifier (DOI)

  • 10.1117/1.1428291

Language

  • eng