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Real-time in vivo color Doppler optical coherence tomography.

Publication ,  Journal Article
Rollins, AM; Yazdanfar, S; Barton, JK; Izatt, JA
Published in: Journal of biomedical optics
January 2002

Color Doppler optical coherence tomography (CDOCT) is a functional extension of optical coherence tomography (OCT) that can image flow in turbid media. We have developed a CDOCT system capable of imaging flow in real time. Doppler processing of the analog signal is accomplished in hardware in the time domain using a novel autocorrelation technique. This Doppler processing method is compatible with a high speed OCT system capable of imaging in real time. Using this system, we demonstrate cross-sectional imaging of bidirectional flow with CDOCT at four frames per second in a tissue-simulating phantom consisting of intralipid solution flowing in glass capillaries. As a demonstration of real-time imaging of blood flow in vivo we imaged pulsatible blood flow in a rat femoral artery at eight frames per second. Issues of velocity sensitivity, imaging speed, and range of velocity measurement are discussed, as well as potential applications of real-time CDOCT.

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Published In

Journal of biomedical optics

DOI

EISSN

1560-2281

ISSN

1083-3668

Publication Date

January 2002

Volume

7

Issue

1

Start / End Page

123 / 129

Related Subject Headings

  • Ultrasonography, Doppler, Color
  • Tomography
  • Time Factors
  • Rheology
  • Rats
  • Phantoms, Imaging
  • Optics and Photonics
  • Optics
  • Models, Theoretical
  • Femoral Artery
 

Citation

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Rollins, A. M., Yazdanfar, S., Barton, J. K., & Izatt, J. A. (2002). Real-time in vivo color Doppler optical coherence tomography. Journal of Biomedical Optics, 7(1), 123–129. https://doi.org/10.1117/1.1428291
Rollins, Andrew M., Siavash Yazdanfar, Jennifer K. Barton, and Joseph A. Izatt. “Real-time in vivo color Doppler optical coherence tomography.Journal of Biomedical Optics 7, no. 1 (January 2002): 123–29. https://doi.org/10.1117/1.1428291.
Rollins AM, Yazdanfar S, Barton JK, Izatt JA. Real-time in vivo color Doppler optical coherence tomography. Journal of biomedical optics. 2002 Jan;7(1):123–9.
Rollins, Andrew M., et al. “Real-time in vivo color Doppler optical coherence tomography.Journal of Biomedical Optics, vol. 7, no. 1, Jan. 2002, pp. 123–29. Epmc, doi:10.1117/1.1428291.
Rollins AM, Yazdanfar S, Barton JK, Izatt JA. Real-time in vivo color Doppler optical coherence tomography. Journal of biomedical optics. 2002 Jan;7(1):123–129.

Published In

Journal of biomedical optics

DOI

EISSN

1560-2281

ISSN

1083-3668

Publication Date

January 2002

Volume

7

Issue

1

Start / End Page

123 / 129

Related Subject Headings

  • Ultrasonography, Doppler, Color
  • Tomography
  • Time Factors
  • Rheology
  • Rats
  • Phantoms, Imaging
  • Optics and Photonics
  • Optics
  • Models, Theoretical
  • Femoral Artery