Molecular contrast in optical coherence tomography by use of a pump-probe technique.

Journal Article

We describe a novel technique for contrast enhancement in optical coherence tomography (OCT) that makes possible molecular-specific imaging for what is believed to be the first time. A pump-probe technique is employed in which a pulsed pump laser is tuned to ground-state absorption in a molecule of interest. The location of the target molecule population is derived from the resulting transient absorption of OCT sample-arm light acting as probe light. A signal processing technique for three-dimensional localization of the transient absorption signal is described, and preliminary results exhibiting OCT contrast from methylene blue dye in multilayer and scattering phantoms are presented.

Full Text

Duke Authors

Cited Authors

  • Rao, KD; Choma, MA; Yazdanfar, S; Rollins, AM; Izatt, JA

Published Date

  • March 1, 2003

Published In

Volume / Issue

  • 28 / 5

Start / End Page

  • 340 - 342

PubMed ID

  • 12659437

International Standard Serial Number (ISSN)

  • 0146-9592


  • eng

Conference Location

  • United States