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Molecular contrast in optical coherence tomography by use of a pump-probe technique.

Publication ,  Journal Article
Rao, KD; Choma, MA; Yazdanfar, S; Rollins, AM; Izatt, JA
Published in: Optics letters
March 2003

We describe a novel technique for contrast enhancement in optical coherence tomography (OCT) that makes possible molecular-specific imaging for what is believed to be the first time. A pump-probe technique is employed in which a pulsed pump laser is tuned to ground-state absorption in a molecule of interest. The location of the target molecule population is derived from the resulting transient absorption of OCT sample-arm light acting as probe light. A signal processing technique for three-dimensional localization of the transient absorption signal is described, and preliminary results exhibiting OCT contrast from methylene blue dye in multilayer and scattering phantoms are presented.

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Published In

Optics letters

DOI

EISSN

1539-4794

ISSN

0146-9592

Publication Date

March 2003

Volume

28

Issue

5

Start / End Page

340 / 342

Related Subject Headings

  • Tomography
  • Optics and Photonics
  • Optics
  • Models, Theoretical
  • Methylene Blue
  • Lasers
  • Contrast Media
  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
 

Citation

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Rao, K. D., Choma, M. A., Yazdanfar, S., Rollins, A. M., & Izatt, J. A. (2003). Molecular contrast in optical coherence tomography by use of a pump-probe technique. Optics Letters, 28(5), 340–342. https://doi.org/10.1364/ol.28.000340
Rao, K Divakar, Michael A. Choma, Siavash Yazdanfar, Andrew M. Rollins, and Joseph A. Izatt. “Molecular contrast in optical coherence tomography by use of a pump-probe technique.Optics Letters 28, no. 5 (March 2003): 340–42. https://doi.org/10.1364/ol.28.000340.
Rao KD, Choma MA, Yazdanfar S, Rollins AM, Izatt JA. Molecular contrast in optical coherence tomography by use of a pump-probe technique. Optics letters. 2003 Mar;28(5):340–2.
Rao, K. Divakar, et al. “Molecular contrast in optical coherence tomography by use of a pump-probe technique.Optics Letters, vol. 28, no. 5, Mar. 2003, pp. 340–42. Epmc, doi:10.1364/ol.28.000340.
Rao KD, Choma MA, Yazdanfar S, Rollins AM, Izatt JA. Molecular contrast in optical coherence tomography by use of a pump-probe technique. Optics letters. 2003 Mar;28(5):340–342.
Journal cover image

Published In

Optics letters

DOI

EISSN

1539-4794

ISSN

0146-9592

Publication Date

March 2003

Volume

28

Issue

5

Start / End Page

340 / 342

Related Subject Headings

  • Tomography
  • Optics and Photonics
  • Optics
  • Models, Theoretical
  • Methylene Blue
  • Lasers
  • Contrast Media
  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering