Molecular contrast in optical coherence tomography by use of a pump-probe technique.
Publication
, Journal Article
Rao, KD; Choma, MA; Yazdanfar, S; Rollins, AM; Izatt, JA
Published in: Optics letters
March 2003
We describe a novel technique for contrast enhancement in optical coherence tomography (OCT) that makes possible molecular-specific imaging for what is believed to be the first time. A pump-probe technique is employed in which a pulsed pump laser is tuned to ground-state absorption in a molecule of interest. The location of the target molecule population is derived from the resulting transient absorption of OCT sample-arm light acting as probe light. A signal processing technique for three-dimensional localization of the transient absorption signal is described, and preliminary results exhibiting OCT contrast from methylene blue dye in multilayer and scattering phantoms are presented.
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Published In
Optics letters
DOI
EISSN
1539-4794
ISSN
0146-9592
Publication Date
March 2003
Volume
28
Issue
5
Start / End Page
340 / 342
Related Subject Headings
- Tomography
- Optics and Photonics
- Optics
- Models, Theoretical
- Methylene Blue
- Lasers
- Contrast Media
- 5102 Atomic, molecular and optical physics
- 4009 Electronics, sensors and digital hardware
- 4006 Communications engineering
Citation
APA
Chicago
ICMJE
MLA
NLM
Rao, K. D., Choma, M. A., Yazdanfar, S., Rollins, A. M., & Izatt, J. A. (2003). Molecular contrast in optical coherence tomography by use of a pump-probe technique. Optics Letters, 28(5), 340–342. https://doi.org/10.1364/ol.28.000340
Rao, K Divakar, Michael A. Choma, Siavash Yazdanfar, Andrew M. Rollins, and Joseph A. Izatt. “Molecular contrast in optical coherence tomography by use of a pump-probe technique.” Optics Letters 28, no. 5 (March 2003): 340–42. https://doi.org/10.1364/ol.28.000340.
Rao KD, Choma MA, Yazdanfar S, Rollins AM, Izatt JA. Molecular contrast in optical coherence tomography by use of a pump-probe technique. Optics letters. 2003 Mar;28(5):340–2.
Rao, K. Divakar, et al. “Molecular contrast in optical coherence tomography by use of a pump-probe technique.” Optics Letters, vol. 28, no. 5, Mar. 2003, pp. 340–42. Epmc, doi:10.1364/ol.28.000340.
Rao KD, Choma MA, Yazdanfar S, Rollins AM, Izatt JA. Molecular contrast in optical coherence tomography by use of a pump-probe technique. Optics letters. 2003 Mar;28(5):340–342.
Published In
Optics letters
DOI
EISSN
1539-4794
ISSN
0146-9592
Publication Date
March 2003
Volume
28
Issue
5
Start / End Page
340 / 342
Related Subject Headings
- Tomography
- Optics and Photonics
- Optics
- Models, Theoretical
- Methylene Blue
- Lasers
- Contrast Media
- 5102 Atomic, molecular and optical physics
- 4009 Electronics, sensors and digital hardware
- 4006 Communications engineering