Molecular contrast in optical coherence tomography by use of a pump-probe technique.
Journal Article (Journal Article)
We describe a novel technique for contrast enhancement in optical coherence tomography (OCT) that makes possible molecular-specific imaging for what is believed to be the first time. A pump-probe technique is employed in which a pulsed pump laser is tuned to ground-state absorption in a molecule of interest. The location of the target molecule population is derived from the resulting transient absorption of OCT sample-arm light acting as probe light. A signal processing technique for three-dimensional localization of the transient absorption signal is described, and preliminary results exhibiting OCT contrast from methylene blue dye in multilayer and scattering phantoms are presented.
- Rao, KD; Choma, MA; Yazdanfar, S; Rollins, AM; Izatt, JA
- March 2003
Volume / Issue
- 28 / 5
Start / End Page
- 340 - 342
Electronic International Standard Serial Number (EISSN)
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)