Protein-based molecular contrast optical coherence tomography with phytochrome as the contrast agent.
Publication
, Journal Article
Yang, C; Choma, MA; Lamb, LE; Simon, JD; Izatt, JA
Published in: Optics letters
June 2004
We report the use of phytochrome A (phyA), a plant protein that can reversibly switch between two states with different absorption maxima (at 660 and 730 nm), as a contrast agent for molecular contrast optical coherence tomography (MCOCT). Our MCOCT scheme builds up a difference image revealing the distribution of phyA within a target sample from pairs of consecutive OCT A-scans acquired at a probe wavelength of 750 nm, both with and without additional illumination of the target sample with 660-nm light. We demonstrate molecular imaging with this new MCOCT modality in a target sample containing a mixture of 0.2% Intralipid and 83 microM of phyA.
Duke Scholars
Published In
Optics letters
DOI
EISSN
1539-4794
ISSN
0146-9592
Publication Date
June 2004
Volume
29
Issue
12
Start / End Page
1396 / 1398
Related Subject Headings
- Tomography, Optical Coherence
- Phytochrome A
- Phytochrome
- Optics
- Molecular Probes
- Molecular Probe Techniques
- Feasibility Studies
- Fat Emulsions, Intravenous
- Contrast Media
- 5102 Atomic, molecular and optical physics
Citation
APA
Chicago
ICMJE
MLA
NLM
Yang, C., Choma, M. A., Lamb, L. E., Simon, J. D., & Izatt, J. A. (2004). Protein-based molecular contrast optical coherence tomography with phytochrome as the contrast agent. Optics Letters, 29(12), 1396–1398. https://doi.org/10.1364/ol.29.001396
Yang, Changhuei, Michael A. Choma, Laura E. Lamb, John D. Simon, and Joseph A. Izatt. “Protein-based molecular contrast optical coherence tomography with phytochrome as the contrast agent.” Optics Letters 29, no. 12 (June 2004): 1396–98. https://doi.org/10.1364/ol.29.001396.
Yang C, Choma MA, Lamb LE, Simon JD, Izatt JA. Protein-based molecular contrast optical coherence tomography with phytochrome as the contrast agent. Optics letters. 2004 Jun;29(12):1396–8.
Yang, Changhuei, et al. “Protein-based molecular contrast optical coherence tomography with phytochrome as the contrast agent.” Optics Letters, vol. 29, no. 12, June 2004, pp. 1396–98. Epmc, doi:10.1364/ol.29.001396.
Yang C, Choma MA, Lamb LE, Simon JD, Izatt JA. Protein-based molecular contrast optical coherence tomography with phytochrome as the contrast agent. Optics letters. 2004 Jun;29(12):1396–1398.
Published In
Optics letters
DOI
EISSN
1539-4794
ISSN
0146-9592
Publication Date
June 2004
Volume
29
Issue
12
Start / End Page
1396 / 1398
Related Subject Headings
- Tomography, Optical Coherence
- Phytochrome A
- Phytochrome
- Optics
- Molecular Probes
- Molecular Probe Techniques
- Feasibility Studies
- Fat Emulsions, Intravenous
- Contrast Media
- 5102 Atomic, molecular and optical physics