Frequency estimation precision in Doppler optical coherence tomography using the Cramer-Rao lower bound.


Journal Article

Doppler optical coherence tomography (DOCT) is a technique for simultaneous cross-sectional imaging of tissue structure and blood flow. We derive the fundamental uncertainty limits on frequency estimation precision in DOCT using the Cramer-Rao lower bound in the case of additive (e.g., thermal, shot) noise. Experimental results from a mirror and a scattering phantom are used to verify the theoretical limits. Our results demonstrate that the stochastic nature of frequency noise influences the precision of flow imaging, and that the noise model must be selected judiciously in order to estimate the frequency precision.

Full Text

Duke Authors

Cited Authors

  • Yazdanfar, S; Yang, C; Sarunic, M; Izatt, J

Published Date

  • January 2005

Published In

Volume / Issue

  • 13 / 2

Start / End Page

  • 410 - 416

PubMed ID

  • 19488367

Pubmed Central ID

  • 19488367

Electronic International Standard Serial Number (EISSN)

  • 1094-4087

International Standard Serial Number (ISSN)

  • 1094-4087

Digital Object Identifier (DOI)

  • 10.1364/opex.13.000410


  • eng