Recent developments in optical coherence tomography

Recent developments in Optical coherence tomography (OCT) include the continued development of endoscopic OCT as a prime example of a biomedical optics technology which is making the transition from the laboratory bench to the clinical bedside. Multi-center trials of endoscopic OCT are now underway using technology developed at our institution, and are showing strong promise for early detection of cancer in endoscopically accessible tissues. Novel enhancements to OCT technology are also being developed, and include capabilities for real-time imaging in the anterior segment of the eye, as well as enhancements for extracting spectroscopic features of tissues being examined. An excellent example of spectroscopic OCT is the technique of color Doppler OCT, which we have developed for noninvasive, cross-sectional imaging of blood flow in the retina with micron-scale resolution.