Digital signal processing in optical coherence tomography


Journal Article

Optical Coherence Tomography (OCT) is a novel medical imaging modality which utilizes coherence ranging to perform high resolution (∼10 μm) non-invasive sub- surface imaging of biostructures. We have developed an OCT system consisting of a low-coherence interferometer and a calibration interferometer allowing sub-micron interferogram acquisition accuracy. We propose some digital signal processing strategies for image enhancement in optical coherence tomography. A linear shift invariant system model is presented for describing coherent light-tissue interactions in optical coherence tomography. In this model, the electric field backscattered from a target specimen is treated as a convolution of the incident field and a postulated tissue impulse response which describes the profile of scattering sites within the specimen. Based on this model, a novel technique for enhancing the sharpness of optical coherence tomographic images of biological structures using digital deconvolution is demonstrated. Using this approach, resolution improvement by a factor of > 2.2 is achieved in the longitudinal direction. ©2004 Copyright SPIE - The International Society for Optical Engineering.

Full Text

Duke Authors

Cited Authors

  • Kulkarni, MD; Izatt, JA

Published Date

  • December 1, 1997

Published In

Volume / Issue

  • 2981 /

Start / End Page

  • 2 - 6

International Standard Serial Number (ISSN)

  • 0277-786X

Digital Object Identifier (DOI)

  • 10.1117/12.274307

Citation Source

  • Scopus