Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent.


Journal Article

We report a new molecular contrast optical coherence tomography (MCOCT) implementation that profiles the contrast agent distribution in a sample by measuring the agent's spectral differential absorption. The method, spectra triangulation MCOCT, can effectively suppress contributions from spectrally dependent scatterings from the sample without a priori knowledge of the scattering properties. We demonstrate molecular imaging with this new MCOCT modality by mapping the distribution of indocyanine green, a FDA-approved infrared red dye, within a stage 54 Xenopus laevis.

Full Text

Duke Authors

Cited Authors

  • Yang, C; McGuckin, LEL; Simon, JD; Choma, MA; Applegate, BE; Izatt, JA

Published Date

  • September 2004

Published In

Volume / Issue

  • 29 / 17

Start / End Page

  • 2016 - 2018

PubMed ID

  • 15455765

Pubmed Central ID

  • 15455765

Electronic International Standard Serial Number (EISSN)

  • 1539-4794

International Standard Serial Number (ISSN)

  • 0146-9592

Digital Object Identifier (DOI)

  • 10.1364/ol.29.002016


  • eng