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Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent.

Publication ,  Journal Article
Yang, C; McGuckin, LEL; Simon, JD; Choma, MA; Applegate, BE; Izatt, JA
Published in: Optics letters
September 2004

We report a new molecular contrast optical coherence tomography (MCOCT) implementation that profiles the contrast agent distribution in a sample by measuring the agent's spectral differential absorption. The method, spectra triangulation MCOCT, can effectively suppress contributions from spectrally dependent scatterings from the sample without a priori knowledge of the scattering properties. We demonstrate molecular imaging with this new MCOCT modality by mapping the distribution of indocyanine green, a FDA-approved infrared red dye, within a stage 54 Xenopus laevis.

Duke Scholars

Published In

Optics letters

DOI

EISSN

1539-4794

ISSN

0146-9592

Publication Date

September 2004

Volume

29

Issue

17

Start / End Page

2016 / 2018

Related Subject Headings

  • Xenopus laevis
  • Tomography, Optical Coherence
  • Spectrum Analysis
  • Optics
  • Indocyanine Green
  • Image Interpretation, Computer-Assisted
  • Image Enhancement
  • Feasibility Studies
  • Contrast Media
  • Animals
 

Citation

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MLA
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Yang, C., McGuckin, L. E. L., Simon, J. D., Choma, M. A., Applegate, B. E., & Izatt, J. A. (2004). Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent. Optics Letters, 29(17), 2016–2018. https://doi.org/10.1364/ol.29.002016
Yang, Changhuei, Laura E. L. McGuckin, John D. Simon, Michael A. Choma, Brian E. Applegate, and Joseph A. Izatt. “Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent.Optics Letters 29, no. 17 (September 2004): 2016–18. https://doi.org/10.1364/ol.29.002016.
Yang C, McGuckin LEL, Simon JD, Choma MA, Applegate BE, Izatt JA. Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent. Optics letters. 2004 Sep;29(17):2016–8.
Yang, Changhuei, et al. “Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent.Optics Letters, vol. 29, no. 17, Sept. 2004, pp. 2016–18. Epmc, doi:10.1364/ol.29.002016.
Yang C, McGuckin LEL, Simon JD, Choma MA, Applegate BE, Izatt JA. Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent. Optics letters. 2004 Sep;29(17):2016–2018.
Journal cover image

Published In

Optics letters

DOI

EISSN

1539-4794

ISSN

0146-9592

Publication Date

September 2004

Volume

29

Issue

17

Start / End Page

2016 / 2018

Related Subject Headings

  • Xenopus laevis
  • Tomography, Optical Coherence
  • Spectrum Analysis
  • Optics
  • Indocyanine Green
  • Image Interpretation, Computer-Assisted
  • Image Enhancement
  • Feasibility Studies
  • Contrast Media
  • Animals