Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging.


Journal Article

We have combined Fourier-domain optical coherence tomography (FD-OCT) with a closed-loop adaptive optics (AO) system using a Hartmann-Shack wavefront sensor and a bimorph deformable mirror. The adaptive optics system measures and corrects the wavefront aberration of the human eye for improved lateral resolution (~4 μm) of retinal images, while maintaining the high axial resolution (~6 μm) of stand alone OCT. The AO-OCT instrument enables the three-dimensional (3D) visualization of different retinal structures in vivo with high 3D resolution (4×4×6 μm). Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.

Full Text

Duke Authors

Cited Authors

  • Zawadzki, RJ; Jones, SM; Olivier, SS; Zhao, M; Bower, BA; Izatt, JA; Choi, S; Laut, S; Werner, JS

Published Date

  • October 2005

Published In

Volume / Issue

  • 13 / 21

Start / End Page

  • 8532 - 8546

PubMed ID

  • 19096728

Pubmed Central ID

  • 19096728

Electronic International Standard Serial Number (EISSN)

  • 1094-4087

International Standard Serial Number (ISSN)

  • 1094-4087

Digital Object Identifier (DOI)

  • 10.1364/opex.13.008532


  • eng