Polarization-resolved second-harmonic-generation optical coherence tomography in collagen.

Journal Article (Journal Article)

We describe a novel imaging technique, second-harmonic-generation optical coherence tomography (SHOCT). This technique combines the spatial resolution and depth penetration of optical coherence tomography (OCT) with the molecular sensitivity of second-harmonic-generation spectroscopy. As a consequence of the coherent detection required for OCT, polarization-resolved images arise naturally. We demonstrate this new technique on a skin sample from the belly of Icelandic salmon, acquiring polarization-resolved SHOCT and OCT images simultaneously.

Full Text

Duke Authors

Cited Authors

  • Applegate, BE; Yang, C; Rollins, AM; Izatt, JA

Published Date

  • October 2004

Published In

Volume / Issue

  • 29 / 19

Start / End Page

  • 2252 - 2254

PubMed ID

  • 15524371

Electronic International Standard Serial Number (EISSN)

  • 1539-4794

International Standard Serial Number (ISSN)

  • 0146-9592

Digital Object Identifier (DOI)

  • 10.1364/ol.29.002252


  • eng