In vivo imaging of blood flow dynamics using color Doppler optical coherence tomography
Noninvasive quantitation of blood flow in the retinal microcirculation may elucidate the progression and treatment of ocular disorders including diabetic retinopathy, age-related macular degeneration, and glaucoma. Color Doppler optical coherence tomography (CDOCT) was recently introduced as a technique allowing simultaneous micron-scale resolution cross-sectional imaging of tissue microstructure and blood flow in the human retina. Here, time-resolved imaging of dynamics of blood flow profiles was performed to measure cardiac pulsatility within retinal vessels. Retinal pulsatility has been shown to decrease throughout the progression of diabetic retinopathy.