Skip to main content
Journal cover image

Electroporation and shock-induced transmembrane potential in a cardiac fiber during defibrillation strength shocks.

Publication ,  Journal Article
DeBruin, KA; Krassowska, W
Published in: Annals of biomedical engineering
July 1998

Experimental studies have shown that the magnitude of the shock-induced transmembrane potential (Vm) saturates with increasing electric field strength. This study uses a mathematical model to investigate the effects of electroporation and membrane kinetics on Vm in a cardiac fiber. The model consists of the core conductor equation for a one-dimensional fiber, where excitability is represented by the Luo-Rudy dynamic model (1994-1995) and electroporation is described by a membrane conductance that increases exponentially with Vm squared. For shocks delivered during the plateau of an action potential, the model reproduces the experimentally observed saturation of Vm with a root mean square error of 4.27% and a correlation coefficient of 0.9992. For shocks delivered during diastole, the saturation of Vm is qualitatively reproduced even when the sodium and calcium channels are inactivated. Quantitative replication of the response to diastolic shocks is hindered by the choice of electroporation parameters (optimized for shocks delivered during the plateau) and differences in the membrane kinetics between model and experiment. The complex behavior of Vm during large shocks is due to a combination of electroporation, electrotonus, propagation, and active membrane kinetics. The modeling results imply that the experimentally observed saturation of Vm is due to electroporation of the lipid bilayer.

Duke Scholars

Published In

Annals of biomedical engineering

DOI

EISSN

1573-9686

ISSN

0090-6964

Publication Date

July 1998

Volume

26

Issue

4

Start / End Page

584 / 596

Related Subject Headings

  • Tetrodotoxin
  • Perfusion
  • Models, Cardiovascular
  • Membrane Potentials
  • In Vitro Techniques
  • Heart
  • Guinea Pigs
  • Electroporation
  • Electric Stimulation
  • Electric Countershock
 

Citation

APA
Chicago
ICMJE
MLA
NLM
DeBruin, K. A., & Krassowska, W. (1998). Electroporation and shock-induced transmembrane potential in a cardiac fiber during defibrillation strength shocks. Annals of Biomedical Engineering, 26(4), 584–596. https://doi.org/10.1114/1.101
DeBruin, K. A., and W. Krassowska. “Electroporation and shock-induced transmembrane potential in a cardiac fiber during defibrillation strength shocks.Annals of Biomedical Engineering 26, no. 4 (July 1998): 584–96. https://doi.org/10.1114/1.101.
DeBruin KA, Krassowska W. Electroporation and shock-induced transmembrane potential in a cardiac fiber during defibrillation strength shocks. Annals of biomedical engineering. 1998 Jul;26(4):584–96.
DeBruin, K. A., and W. Krassowska. “Electroporation and shock-induced transmembrane potential in a cardiac fiber during defibrillation strength shocks.Annals of Biomedical Engineering, vol. 26, no. 4, July 1998, pp. 584–96. Epmc, doi:10.1114/1.101.
DeBruin KA, Krassowska W. Electroporation and shock-induced transmembrane potential in a cardiac fiber during defibrillation strength shocks. Annals of biomedical engineering. 1998 Jul;26(4):584–596.
Journal cover image

Published In

Annals of biomedical engineering

DOI

EISSN

1573-9686

ISSN

0090-6964

Publication Date

July 1998

Volume

26

Issue

4

Start / End Page

584 / 596

Related Subject Headings

  • Tetrodotoxin
  • Perfusion
  • Models, Cardiovascular
  • Membrane Potentials
  • In Vitro Techniques
  • Heart
  • Guinea Pigs
  • Electroporation
  • Electric Stimulation
  • Electric Countershock