Experimental proof of the feasibility of using an angled fiber-optic probe for depth-sensitive fluorescence spectroscopy of turbid media.


Journal Article

An angled fiber-optic probe that facilitates depth-sensitive fluorescence measurements was developed for enhancing detection of epithelial precancers. The probe was tested on solid, two-layered phantoms and proved to be effective in selectively detecting fluorescence from different layers. Specifically, a larger illumination angle provides greater sensitivity to fluorescence from the top layer as well as yielding an overall higher fluorescence signal. Monte Carlo simulations of a theoretical model of the phantoms demonstrate that increasing the illumination angle results in an increased excitation photon density and, thus, in increased fluorescence generated in the top layer.

Full Text

Cited Authors

  • Liu, Q; Ramanujam, N

Published Date

  • September 1, 2004

Published In

Volume / Issue

  • 29 / 17

Start / End Page

  • 2034 - 2036

PubMed ID

  • 15455771

Pubmed Central ID

  • 15455771

International Standard Serial Number (ISSN)

  • 0146-9592

Digital Object Identifier (DOI)

  • 10.1364/ol.29.002034


  • eng

Conference Location

  • United States