Fourier-domain low-coherence interferometry for light-scattering spectroscopy.

Journal Article (Journal Article)

We present a novel method for obtaining depth-resolved spectra for determining scatterer size through elastic-scattering properties. Depth resolution is achieved with a white-light source in a Michelson interferometer with the mixed signal and reference fields dispersed by a spectrograph. The spectrum is Fourier transformed to yield the axial spatial cross correlation between the signal and reference fields with near 1-microm depth resolution. Spectral information is obtained by windowing to yield the scattering amplitude as a function of wave number. The technique is demonstrated by determination of the size of polystyrene microspheres in a subsurface layer with subwavelength accuracy. Application of the technique to probing the size of cell nuclei in living epithelial tissues is discussed.

Full Text

Duke Authors

Cited Authors

  • Wax, A; Yang, C; Izatt, JA

Published Date

  • July 2003

Published In

Volume / Issue

  • 28 / 14

Start / End Page

  • 1230 - 1232

PubMed ID

  • 12885030

Electronic International Standard Serial Number (EISSN)

  • 1539-4794

International Standard Serial Number (ISSN)

  • 0146-9592

Digital Object Identifier (DOI)

  • 10.1364/ol.28.001230


  • eng