Metallic nanostructures for plasmonic sensors using surface-enhanced fluorescence and Raman detection
Published
Journal Article
We present the fabrication and characterization of silver island films with SiO 2 coatings for application in plasmonic sensors based on surface-enhanced fluorescence and Raman detection. The emission spectral properties of goat anti-mouse immunoglobulin (IgG) F(ab′) 2 labeled with one or two fluorescein residues were examined on substrates with metallic silver islands. The self-quenching of fluorescein emission was mostly eliminated when this antibody fragment was held 60-90 A from the surface of metallic silver islands, and our preliminary experiments demonstrated an 8-fold emission intensity increase. Similar surfaces were also examined for surface-enhanced Raman analysis of Rhodamine 123, a potential drug for photodynamic therapy.
Full Text
Duke Authors
Cited Authors
- Yan, F; Wabuyele, MB; Griffin, GD; Vo-Dinh, T
Published Date
- November 16, 2004
Published In
Volume / Issue
- 5327 /
Start / End Page
- 53 - 59
International Standard Serial Number (ISSN)
- 0277-786X
Digital Object Identifier (DOI)
- 10.1117/12.542455
Citation Source
- Scopus