Metallic nanostructures for plasmonic sensors using surface-enhanced fluorescence and Raman detection

Journal Article

We present the fabrication and characterization of silver island films with SiO 2 coatings for application in plasmonic sensors based on surface-enhanced fluorescence and Raman detection. The emission spectral properties of goat anti-mouse immunoglobulin (IgG) F(ab′) 2 labeled with one or two fluorescein residues were examined on substrates with metallic silver islands. The self-quenching of fluorescein emission was mostly eliminated when this antibody fragment was held 60-90 A from the surface of metallic silver islands, and our preliminary experiments demonstrated an 8-fold emission intensity increase. Similar surfaces were also examined for surface-enhanced Raman analysis of Rhodamine 123, a potential drug for photodynamic therapy.

Full Text

Duke Authors

Cited Authors

  • Yan, F; Wabuyele, MB; Griffin, GD; Vo-Dinh, T

Published Date

  • November 16, 2004

Published In

Volume / Issue

  • 5327 /

Start / End Page

  • 53 - 59

International Standard Serial Number (ISSN)

  • 0277-786X

Digital Object Identifier (DOI)

  • 10.1117/12.542455

Citation Source

  • Scopus