Phase-resolved fiber-optics fluoroimmunosensor

Journal Article (Journal Article)

This paper describes the development and application of a phase-resolved fiber-optics fluoroimmunosensor (PR-FIS), which combines the biochemical specificity of antigen-antibody reaction, the high sensitivity of laser excitation, the versatility of fiber-optics sensors, and the selectivity of phase-resolved detection. The PR-FIS device can differentiate benzo(a)pyrene and benzo(a)pyrene tetrol, a DNA-adduct product of the carcinogen benzo(a)pyrene. Benzo(a)pyrene tetrol can be detected at femtomole levels in the presence of an amount of interfacing benzo(a)pyrene that is 50-fold more concentrated.

Full Text

Duke Authors

Cited Authors

  • Vo-Dinh, T; Nolan, T; Cheng, YF; Sepaniak, MJ; Alarie, JP

Published Date

  • January 1, 1990

Published In

Volume / Issue

  • 44 / 1

Start / End Page

  • 128 - 132

International Standard Serial Number (ISSN)

  • 0003-7028

Digital Object Identifier (DOI)

  • 10.1366/0003702904085859

Citation Source

  • Scopus