An AOTF-based dual-modality hyperspectral imaging system (DMHSI) capable of simultaneous fluorescence and reflectance imaging.

Journal Article (Journal Article)

An acousto-optic tunable filter (AOTF)-based system for dual-modality hyperspectral imaging (DMHSI) has been developed for use in characterization of normal and malignant mouse tissue. The system consists of a laser, endoscope, AOTF, and two cameras coupled with optics and electronics. Initial results show that the system can delineate normal and malignant mouse tissues real-time. The analysis shows that malignant tissues consistently exhibit less fluorescent intensity in the wavelength band from 440 to 540 nm with a peak intensity of around 490 nm. The analysis also shows key spectroscopic differences between normal and malignant tissues. Further, these results are compared to real-time spectroscopic data and show good correlation.

Full Text

Duke Authors

Cited Authors

  • Martin, ME; Wabuyele, M; Panjehpour, M; Overholt, B; DeNovo, R; Kennel, S; Cunningham, G; Vo-Dinh, T

Published Date

  • March 2006

Published In

Volume / Issue

  • 28 / 2

Start / End Page

  • 149 - 155

PubMed ID

  • 15955718

Electronic International Standard Serial Number (EISSN)

  • 1873-4030

International Standard Serial Number (ISSN)

  • 1350-4533

Digital Object Identifier (DOI)

  • 10.1016/j.medengphy.2005.04.022


  • eng