An AOTF-based dual-modality hyperspectral imaging system (DMHSI) capable of simultaneous fluorescence and reflectance imaging.
Journal Article (Journal Article)
An acousto-optic tunable filter (AOTF)-based system for dual-modality hyperspectral imaging (DMHSI) has been developed for use in characterization of normal and malignant mouse tissue. The system consists of a laser, endoscope, AOTF, and two cameras coupled with optics and electronics. Initial results show that the system can delineate normal and malignant mouse tissues real-time. The analysis shows that malignant tissues consistently exhibit less fluorescent intensity in the wavelength band from 440 to 540 nm with a peak intensity of around 490 nm. The analysis also shows key spectroscopic differences between normal and malignant tissues. Further, these results are compared to real-time spectroscopic data and show good correlation.
Full Text
Duke Authors
Cited Authors
- Martin, ME; Wabuyele, M; Panjehpour, M; Overholt, B; DeNovo, R; Kennel, S; Cunningham, G; Vo-Dinh, T
Published Date
- March 2006
Published In
Volume / Issue
- 28 / 2
Start / End Page
- 149 - 155
PubMed ID
- 15955718
Electronic International Standard Serial Number (EISSN)
- 1873-4030
International Standard Serial Number (ISSN)
- 1350-4533
Digital Object Identifier (DOI)
- 10.1016/j.medengphy.2005.04.022
Language
- eng