Surface-Enhanced Raman Analysis of Benzo[A]Pyrene-DNA Adducts on Silver-Coated Cellulose Substrates

Journal Article

Benzo[a]pyrene-7,8-diol-9,10 epoxide (BPDE)-DNA adducts have been analyzed by surface-enhanced Raman scattering (SERS) spectrometry. BPDE is the ultimate carcinogenic metabolite of benzo[a]pyrene. The SERS measurements were performed with the use of a silver-coated cellulose material as the SERS-active substrate. The acid hydrolyzed products of BPDE-DNA adducts, DNA, and the BP-tetrols were also analyzed by SERS. The results indicate that SERS has great promise as a tool for detecting BPDE-DNA adducts in biological samples.

Full Text

Duke Authors

Cited Authors

  • Vo-Dinh, T; Uziel, M; Morrison, AL

Published Date

  • May 1987

Published In

Volume / Issue

  • 41 / 4

Start / End Page

  • 605 - 610

Published By

Electronic International Standard Serial Number (EISSN)

  • 1943-3530

International Standard Serial Number (ISSN)

  • 0003-7028

Digital Object Identifier (DOI)

  • 10.1366/0003702874448616

Language

  • en