Laser-induced fluorescence for the detection of esophageal and skin cancer


Journal Article

Laser-induced fluorescence (LIF) is used for in-vivo cancer diagnosis of the esophagus and skin cancer. For esophageal measurements a fiberoptic probe inserted through an endoscope was used. Autofluorescence of normal and malignant tissues were measured directly on patient skin without requiring an endoscope. Measurement of the fluorescence signal from the tissue was performed using laser excitation at 410 nm. The methodology was applied to differentiate normal and malignant tumors of the esophagus and malignant skin lesions. The results of this LIF approach were compared with histopathology results of the biopsy samples and indicated excellent agreement in the classification of normal and malignant tumors for the samples investigated.

Full Text

Duke Authors

Cited Authors

  • Vo-Dinh, T; Panjehpour, M; Overholt, BF; Julius, C; Overholt, S; Phan, MN

Published Date

  • December 5, 2003

Published In

Volume / Issue

  • 4958 /

Start / End Page

  • 67 - 70

International Standard Serial Number (ISSN)

  • 0277-786X

Digital Object Identifier (DOI)

  • 10.1117/12.488678

Citation Source

  • Scopus