Development of an advanced hyperspectral imaging (HSI) system with applications for cancer detection.

Journal Article (Journal Article)

An advanced hyper-spectral imaging (HSI) system has been developed having obvious applications for cancer detection. This HSI system is based on state-of-the-art liquid crystal tunable filter technology coupled to an endoscope. The goal of this unique HSI technology being developed is to obtain spatially resolved images of the slight differences in luminescent properties of malignant versus non-malignant tissues. In this report, the development of the instrument is discussed and the capability of the instrument is demonstrated by observing mouse carcinomas in-vivo. It is shown that the instrument successfully distinguishes between normal and malignant mouse skin. It is hoped that the results of this study will lead to advances in the optical diagnosis of cancer in humans.

Full Text

Duke Authors

Cited Authors

  • Martin, ME; Wabuyele, MB; Chen, K; Kasili, P; Panjehpour, M; Phan, M; Overholt, B; Cunningham, G; Wilson, D; Denovo, RC; Vo-Dinh, T

Published Date

  • June 2006

Published In

Volume / Issue

  • 34 / 6

Start / End Page

  • 1061 - 1068

PubMed ID

  • 16783661

Electronic International Standard Serial Number (EISSN)

  • 1573-9686

International Standard Serial Number (ISSN)

  • 0090-6964

Digital Object Identifier (DOI)

  • 10.1007/s10439-006-9121-9


  • eng