Integrated CMOS microchip system with capillary array electrophoresis.

Journal Article (Journal Article)

A complementary metal oxide semiconductor (CMOS)-capillary array electrophoresis (CAE) system has been used for DNA analysis. Because of its compactness and multiplex capability, the CAE-CMOS microchip is very suitable for the construction of a miniaturized high-throughput system for bioassays. Use of simultaneous laser-beam focusing on to the capillary array and a microscope objective contributed to the construction of the compact CMOS microchip-CAE system. To test the constructed system 100-base-pair (bp) DNA ladders and Hind III digest lambda DNA were separated in poly(vinylpyrrolidone) (PVP) sieving matrix. The miniaturized and integrated CMOS microchip system used in this work had great potential for combination with a variety of microfabricated devices for biomedical research.

Full Text

Duke Authors

Cited Authors

  • Song Joon, M; Vo-Dinh, T

Published Date

  • July 2002

Published In

Volume / Issue

  • 373 / 6

Start / End Page

  • 399 - 403

PubMed ID

  • 12172674

Electronic International Standard Serial Number (EISSN)

  • 1618-2650

International Standard Serial Number (ISSN)

  • 1618-2642

Digital Object Identifier (DOI)

  • 10.1007/s00216-002-1353-4


  • eng