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Use of short-pulse laser for optical tomography of tissues

Publication ,  Journal Article
Mitra, K; Vo-Dinh, T
Published in: Proceedings of SPIE - The International Society for Optical Engineering
January 1, 2001

This paper analyzes the short pulse laser propagation through tissues for development of a time-resolved optical tomography system for detection of tumors and inhomogeneities in tissues. Traditional method for analyzing optical transport in tissues is the parabolic or diffusion approximation in which the energy flux is assumed proportional to the fluence (intensity averaged over all solid angles) gradients. The inherent drawback in this model is that it predicts infinite speed of propagation of the optical signal. In this paper accurate hyperbolic or wave nature of transient radiative transfer formulation is used to overcome such drawbacks. The transmitted and reflected intensity distributions are obtained using hyperbolic P1 and discrete ordinates method and the results are compared with the parabolic diffusion P1 approximation. Parametric study of tissue thickness, pulse width, scattering and absorption coefficients of tissues, tumor location, size and properties, and scattering phase function distribution is also performed to analyze their effect on the transmitted and reflected optical signals.

Duke Scholars

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

ISSN

0277-786X

Publication Date

January 1, 2001

Volume

4254

Start / End Page

61 / 71

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
 

Citation

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Mitra, K., & Vo-Dinh, T. (2001). Use of short-pulse laser for optical tomography of tissues. Proceedings of SPIE - The International Society for Optical Engineering, 4254, 61–71. https://doi.org/10.1117/12.427953
Mitra, K., and T. Vo-Dinh. “Use of short-pulse laser for optical tomography of tissues.” Proceedings of SPIE - The International Society for Optical Engineering 4254 (January 1, 2001): 61–71. https://doi.org/10.1117/12.427953.
Mitra K, Vo-Dinh T. Use of short-pulse laser for optical tomography of tissues. Proceedings of SPIE - The International Society for Optical Engineering. 2001 Jan 1;4254:61–71.
Mitra, K., and T. Vo-Dinh. “Use of short-pulse laser for optical tomography of tissues.” Proceedings of SPIE - The International Society for Optical Engineering, vol. 4254, Jan. 2001, pp. 61–71. Scopus, doi:10.1117/12.427953.
Mitra K, Vo-Dinh T. Use of short-pulse laser for optical tomography of tissues. Proceedings of SPIE - The International Society for Optical Engineering. 2001 Jan 1;4254:61–71.

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

ISSN

0277-786X

Publication Date

January 1, 2001

Volume

4254

Start / End Page

61 / 71

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering