A fiberoptic antibody-based biosensor with time-resolved detection
A phase-resolved fiberoptic antibody-based biosensor is desci ibed, which combines the biochemical specificity of antigen-antibody reaction, the high sensitivity of laser excitation, the versatility of fiberoptic sensors, and the selectivity of phase-resolved detection. The device can differentiate benzo(a)pyrene and benzo(a)pyrene tetrol, a DNA-adduct product of the carcinogen benzo(a)pyrene. The limit of detection of benzo(a)pyrene tetrol is in the attomole range (10-18moles). © 1990 SPIE.
Vo-Dinh, T; Nolan, T; Cheng, YF; Alarie, JP; Sepaniak, MJ
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