Development of a multiarray biosensor for DNA diagnostics


Journal Article

This work involves the development and evaluation of a multiarray biosensor for DNA diagnostics. The evaluation of various system components developed for the biosensor is discussed. The DNA probes labeled with visible and near infrared (NIR) dyes are evaluated. The detection system uses a two-dimensional charge-coupled device (CCD), Examples of application of gene probes in DNA hybridization experiments and in biomedical diagnosis (detection of the p53 cancer gene) are presented to illustrate the usefulness and potential of the biosensor device.

Full Text

Duke Authors

Cited Authors

  • Vo-Dinh, T; Isola, N; Alarie, JP; Landis, D; Griffin, GD; Allison, S

Published Date

  • January 1, 1998

Published In

Volume / Issue

  • 26 / 5

Start / End Page

  • 503 - 514

International Standard Serial Number (ISSN)

  • 1073-9149

Digital Object Identifier (DOI)

  • 10.1080/10739149808000917

Citation Source

  • Scopus