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Hyperspectral fluorescence imaging for mouse skin tumor detection

Publication ,  Journal Article
Kong, SG; Martin, ME; Vo-Dinh, T
Published in: ETRI Journal
January 1, 2006

This paper presents a hyperspectral imaging technique based on laser-induced fluorescence for non-invasive detection of tumorous tissue on mouse skin. Hyperspectral imaging sensors collect image data in a number of narrow, adjacent spectral bands. Such high-resolution measurement of spectral information reveals contiguous emission spectra at each image pixel useful for the characterization of constituent materials. The hyperspectral image data used in this study are fluorescence images of mouse skin consisting of 21 spectral bands in the visible spectrum of the wavelengths ranging from 440 nm to 640 nm. Fluorescence signal is measured with the use of laser excitation at 337 nm. An acousto-optic tunable filter (AOTF) is used to capture images at 10 nm intervals. All spectral band images are spatially registered with the reference band image at 490 nm to obtain exact pixel correspondences by compensating the spatial offsets caused by the refraction differences in AOTF at different wavelengths during the image capture procedure. The unique fluorescence spectral signatures demonstrate a good separation to differentiate malignant tumors from normal tissues for rapid detection of skin cancers without biopsy.

Duke Scholars

Published In

ETRI Journal

DOI

ISSN

1225-6463

Publication Date

January 1, 2006

Volume

28

Issue

6

Start / End Page

770 / 776

Related Subject Headings

  • Networking & Telecommunications
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
  • 1005 Communications Technologies
  • 0906 Electrical and Electronic Engineering
  • 0806 Information Systems
 

Citation

APA
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ICMJE
MLA
NLM
Kong, S. G., Martin, M. E., & Vo-Dinh, T. (2006). Hyperspectral fluorescence imaging for mouse skin tumor detection. ETRI Journal, 28(6), 770–776. https://doi.org/10.4218/etrij.06.0106.0061
Kong, S. G., M. E. Martin, and T. Vo-Dinh. “Hyperspectral fluorescence imaging for mouse skin tumor detection.” ETRI Journal 28, no. 6 (January 1, 2006): 770–76. https://doi.org/10.4218/etrij.06.0106.0061.
Kong SG, Martin ME, Vo-Dinh T. Hyperspectral fluorescence imaging for mouse skin tumor detection. ETRI Journal. 2006 Jan 1;28(6):770–6.
Kong, S. G., et al. “Hyperspectral fluorescence imaging for mouse skin tumor detection.” ETRI Journal, vol. 28, no. 6, Jan. 2006, pp. 770–76. Scopus, doi:10.4218/etrij.06.0106.0061.
Kong SG, Martin ME, Vo-Dinh T. Hyperspectral fluorescence imaging for mouse skin tumor detection. ETRI Journal. 2006 Jan 1;28(6):770–776.

Published In

ETRI Journal

DOI

ISSN

1225-6463

Publication Date

January 1, 2006

Volume

28

Issue

6

Start / End Page

770 / 776

Related Subject Headings

  • Networking & Telecommunications
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
  • 1005 Communications Technologies
  • 0906 Electrical and Electronic Engineering
  • 0806 Information Systems