Antibody-based biosensor for breast cancer with ultrasonic regeneration.

Journal Article (Journal Article)

We describe a novel method and instrumental setup for regenerating antibodies immobilized on a fiberoptic probe of an immunosensor using ultrasonic irradiation with broadband imaging transducers. The instrumental setup and irradiation conditions for antibody regeneration using ultrasound are described. The results of the measurements with antibody against breast cancer antigen illustrate the effectiveness and potential of the regenerable immunosensor. A 65% removal of the antigens bound to the Mab immobilized on the fiber surface is attained after ultrasound regeneration.

Full Text

Duke Authors

Cited Authors

  • Moreno-Bondi, MC; Mobley, J; Alarie, JP; Vo-Dinh, T

Published Date

  • July 2000

Published In

Volume / Issue

  • 5 / 3

Start / End Page

  • 350 - 354

PubMed ID

  • 10958622

Electronic International Standard Serial Number (EISSN)

  • 1560-2281

International Standard Serial Number (ISSN)

  • 1083-3668

Digital Object Identifier (DOI)

  • 10.1117/1.430006


  • eng