Fiber-optic nanosensors for single-cell monitoring.

Journal Article (Review;Journal Article)

This article is an overview of the fabrication, operating principles, and applications of fiber-optic nanobiosensors with the capability of in-vivo analysis at the single-cell level. Recently, the cross-disciplinary integration of nanotechnology, biology, and photonics has been revolutionizing important areas in molecular biology, especially diagnostics and therapy at the molecular and cellular level. Fiber-optic nanobiosensors are a unique class of biosensor that enable analytical measurements in individual living cells and the probing of individual chemical species in specific locations within a cell. This article provides a review of the research performed in our laboratory and discusses the usefulness and potential of this nanotechnology-based biosensor system in biological research and its applications to biomonitoring of individual cells.

Full Text

Duke Authors

Cited Authors

  • Vo-Dinh, T; Kasili, P

Published Date

  • June 2005

Published In

Volume / Issue

  • 382 / 4

Start / End Page

  • 918 - 925

PubMed ID

  • 15928944

Electronic International Standard Serial Number (EISSN)

  • 1618-2650

International Standard Serial Number (ISSN)

  • 1618-2642

Digital Object Identifier (DOI)

  • 10.1007/s00216-005-3256-7


  • eng