A novel implantable cardiac telemetry system for studying atrial fibrillation.

Published

Journal Article

Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. Most in vivo experimental research on AF is performed in a surgical setting, on animals instrumented by external devices, or using commercial implantable pacemakers. This paper describes a novel implantable cardiac telemetry system, which allows the study of AF remotely in conscious and ambulatory animals over a few month period. To validate this concept, the system was built and implanted in a sheep for 3 months. During this period, the system was used to deliver chronic rapid atrial pacing for AF induction, and to record and measure atrial electrograms and atrial effective refractory period (AERP) daily. During the course of AF induction the AERP decreased, confirming the progression of the electrical remodeling process in the atria. Episodes of paroxysmal AF were successfully induced in the animal. Burst pacing therapy was delivered with the system, however, no AF termination was observed. Result shows that this telemetry-based pacing and monitoring system can be used to study AF in a conscious animal non-invasively for an extended period of time, making this system a unique research tool.

Full Text

Duke Authors

Cited Authors

  • Au-Yeung, K; Johnson, CR; Wolf, PD

Published Date

  • October 2004

Published In

Volume / Issue

  • 25 / 5

Start / End Page

  • 1223 - 1238

PubMed ID

  • 15535187

Pubmed Central ID

  • 15535187

Electronic International Standard Serial Number (EISSN)

  • 1361-6579

International Standard Serial Number (ISSN)

  • 0967-3334

Digital Object Identifier (DOI)

  • 10.1088/0967-3334/25/5/012

Language

  • eng