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Electric fields within cells as a function of membrane resistivity--a model study.

Publication ,  Journal Article
Mossop, BJ; Barr, RC; Zaharoff, DA; Yuan, F
Published in: IEEE transactions on nanobioscience
September 2004

Externally applied electric fields play an important role in many therapeutic modalities, but the fields they produce inside cells remain largely unknown. This study makes use of a three-dimensional model to determine the electric field that exists in the intracellular domain of a 10-microm spherical cell exposed to an applied field of 100 V/cm. The transmembrane potential resulting from the applied field was also determined and its change was compared to those of the intracellular field. The intracellular field increased as the membrane resistance decreased over a wide range of values. The results showed that the intracellular electric field was about 1.1 mV/cm for Rm of 10,000 omega x cm2, increasing to about 111 mV/cm as Rm decreased to 100 omega x cm2. Over this range of Rm the transmembrane potential was nearly constant. The transmembrane potential declined only as Rm decreased below 1 omega x cm2. The simulation results suggest that intracellular electric field depends on Rm in its physiologic range, and may not be negligible in understanding some mechanisms of electric field-mediated therapies.

Duke Scholars

Published In

IEEE transactions on nanobioscience

DOI

EISSN

1558-2639

ISSN

1536-1241

Publication Date

September 2004

Volume

3

Issue

3

Start / End Page

225 / 231

Related Subject Headings

  • Nanoscience & Nanotechnology
  • Models, Biological
  • Membrane Potentials
  • Electromagnetic Fields
  • Electric Impedance
  • Computer Simulation
  • Cell Physiological Phenomena
  • Cell Membrane
  • 4601 Applied computing
  • 4003 Biomedical engineering
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mossop, B. J., Barr, R. C., Zaharoff, D. A., & Yuan, F. (2004). Electric fields within cells as a function of membrane resistivity--a model study. IEEE Transactions on Nanobioscience, 3(3), 225–231. https://doi.org/10.1109/tnb.2004.833703
Mossop, Brian J., Roger C. Barr, David A. Zaharoff, and Fan Yuan. “Electric fields within cells as a function of membrane resistivity--a model study.IEEE Transactions on Nanobioscience 3, no. 3 (September 2004): 225–31. https://doi.org/10.1109/tnb.2004.833703.
Mossop BJ, Barr RC, Zaharoff DA, Yuan F. Electric fields within cells as a function of membrane resistivity--a model study. IEEE transactions on nanobioscience. 2004 Sep;3(3):225–31.
Mossop, Brian J., et al. “Electric fields within cells as a function of membrane resistivity--a model study.IEEE Transactions on Nanobioscience, vol. 3, no. 3, Sept. 2004, pp. 225–31. Epmc, doi:10.1109/tnb.2004.833703.
Mossop BJ, Barr RC, Zaharoff DA, Yuan F. Electric fields within cells as a function of membrane resistivity--a model study. IEEE transactions on nanobioscience. 2004 Sep;3(3):225–231.

Published In

IEEE transactions on nanobioscience

DOI

EISSN

1558-2639

ISSN

1536-1241

Publication Date

September 2004

Volume

3

Issue

3

Start / End Page

225 / 231

Related Subject Headings

  • Nanoscience & Nanotechnology
  • Models, Biological
  • Membrane Potentials
  • Electromagnetic Fields
  • Electric Impedance
  • Computer Simulation
  • Cell Physiological Phenomena
  • Cell Membrane
  • 4601 Applied computing
  • 4003 Biomedical engineering