RTOG quality assurance guidelines for clinical trials using hyperthermia for deep-seated malignancy.

Journal Article

Quality assurance has been vague or lacking in many previous hyperthermia trials. Recent publications by the Hyperthermia Physics Center, the Center for Devices and Regulatory Health, and the Radiation Therapy Oncology Group have described general guidelines for quality assurance in equipment reliability and reproducibility, superficial applications, and microwave techniques. The present report details quality assurance factors that are believed to be important for hyperthermia of deep clinical sites, defined as extending at least 3 cm beyond the skin surface. This document will discuss patient and physician factors, as well as thermometric accuracy, assessment of specific absorption rates (SAR), assurance of adequate coverage of tumors by the energy deposition pattern of the treatment device, and recommended documentation of the location, quantity, and frequency of treatment, specifically oriented to deep hyperthermia. The recommendations are structured to facilitate compliance in multiinstitutional trials.

Full Text

Duke Authors

Cited Authors

  • Sapozink, MD; Corry, PM; Kapp, DS; Myerson, RJ; Dewhirst, MW; Emami, B; Herman, T; Prionas, S; Ryan, T; Samulski, T

Published Date

  • May 1991

Published In

Volume / Issue

  • 20 / 5

Start / End Page

  • 1109 - 1115

PubMed ID

  • 2022513

International Standard Serial Number (ISSN)

  • 0360-3016

Language

  • eng

Conference Location

  • United States