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Characterization of tumour temperature distributions in hyperthermia based on assumed mathematical forms.

Publication ,  Journal Article
Edelstein-Keshet, L; Dewhirst, MW; Oleson, JR; Samulski, TV
Published in: Int J Hyperthermia
1989

Assessing the efficacy of hyperthermia treatments involves three distinct problems: (1) adequately sampling the spatial temperature distribution in a region; (2) defining (a set of) 'descriptors', numerical values which could be used in comparing distinct treatments; (3) testing whether the predictions of prognosis are statistically significant. This paper addresses the first two problems. We use simple assumptions about the tumour geometry and heating pattern to obtain convenient mathematical representations of a temperature distribution, which are then used in defining scalar descriptors such as weighted average temperature TV, and the fraction of tumour volume heated above a given temperature VT/V. Two extreme cases are discussed. In the first, tumour geometry plays the dominant role, and in the second the specific absorption rate (SAR) distribution is assumed to have the greatest influence on the temperature distribution.

Duke Scholars

Published In

Int J Hyperthermia

DOI

ISSN

0265-6736

Publication Date

1989

Volume

5

Issue

6

Start / End Page

757 / 777

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasms
  • Models, Theoretical
  • Mathematics
  • Hyperthermia, Induced
  • Humans
  • Body Temperature
  • Absorption
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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ICMJE
MLA
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Edelstein-Keshet, L., Dewhirst, M. W., Oleson, J. R., & Samulski, T. V. (1989). Characterization of tumour temperature distributions in hyperthermia based on assumed mathematical forms. Int J Hyperthermia, 5(6), 757–777. https://doi.org/10.3109/02656738909140500
Edelstein-Keshet, L., M. W. Dewhirst, J. R. Oleson, and T. V. Samulski. “Characterization of tumour temperature distributions in hyperthermia based on assumed mathematical forms.Int J Hyperthermia 5, no. 6 (1989): 757–77. https://doi.org/10.3109/02656738909140500.
Edelstein-Keshet L, Dewhirst MW, Oleson JR, Samulski TV. Characterization of tumour temperature distributions in hyperthermia based on assumed mathematical forms. Int J Hyperthermia. 1989;5(6):757–77.
Edelstein-Keshet, L., et al. “Characterization of tumour temperature distributions in hyperthermia based on assumed mathematical forms.Int J Hyperthermia, vol. 5, no. 6, 1989, pp. 757–77. Pubmed, doi:10.3109/02656738909140500.
Edelstein-Keshet L, Dewhirst MW, Oleson JR, Samulski TV. Characterization of tumour temperature distributions in hyperthermia based on assumed mathematical forms. Int J Hyperthermia. 1989;5(6):757–777.
Journal cover image

Published In

Int J Hyperthermia

DOI

ISSN

0265-6736

Publication Date

1989

Volume

5

Issue

6

Start / End Page

757 / 777

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasms
  • Models, Theoretical
  • Mathematics
  • Hyperthermia, Induced
  • Humans
  • Body Temperature
  • Absorption
  • 3202 Clinical sciences
  • 1103 Clinical Sciences