Characterization of tumour temperature distributions in hyperthermia based on assumed mathematical forms.

Journal Article (Review)

Assessing the efficacy of hyperthermia treatments involves three distinct problems: (1) adequately sampling the spatial temperature distribution in a region; (2) defining (a set of) 'descriptors', numerical values which could be used in comparing distinct treatments; (3) testing whether the predictions of prognosis are statistically significant. This paper addresses the first two problems. We use simple assumptions about the tumour geometry and heating pattern to obtain convenient mathematical representations of a temperature distribution, which are then used in defining scalar descriptors such as weighted average temperature TV, and the fraction of tumour volume heated above a given temperature VT/V. Two extreme cases are discussed. In the first, tumour geometry plays the dominant role, and in the second the specific absorption rate (SAR) distribution is assumed to have the greatest influence on the temperature distribution.

Full Text

Duke Authors

Cited Authors

  • Edelstein-Keshet, L; Dewhirst, MW; Oleson, JR; Samulski, TV

Published Date

  • November 1989

Published In

Volume / Issue

  • 5 / 6

Start / End Page

  • 757 - 777

PubMed ID

  • 2687400

International Standard Serial Number (ISSN)

  • 0265-6736

Language

  • eng

Conference Location

  • England