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Analysis of oxygen transport to tumors: causes of heterogeneous tissue oxygenation

Publication ,  Journal Article
Secomb, TW; Hsu, R; Braun, RD; Dewhirst, MW
Published in: American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
December 1, 1999

A theoretical model was used to study the factors that contribute to the heterogeneous distribution of tissue pressure of oxygen (PO2) and the occurrence of hypoxic regions in tumors. A Green=s function method was used to predict the distribution of PO2. For purpose of comparison, further calculations were performed in which all vessels were assumed to be at the same PO2, and in which a simple Krogh cylinder model was assumed, with the same vascular density as the simulated region. Finally, the resulting data was analyzed.

Duke Scholars

Published In

American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

Publication Date

December 1, 1999

Volume

42

Start / End Page

487 / 488

Related Subject Headings

  • Biomedical Engineering
 

Citation

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Secomb, T. W., Hsu, R., Braun, R. D., & Dewhirst, M. W. (1999). Analysis of oxygen transport to tumors: causes of heterogeneous tissue oxygenation. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, 42, 487–488.
Secomb, T. W., R. Hsu, R. D. Braun, and M. W. Dewhirst. “Analysis of oxygen transport to tumors: causes of heterogeneous tissue oxygenation.” American Society of Mechanical Engineers, Bioengineering Division (Publication) BED 42 (December 1, 1999): 487–88.
Secomb TW, Hsu R, Braun RD, Dewhirst MW. Analysis of oxygen transport to tumors: causes of heterogeneous tissue oxygenation. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 1999 Dec 1;42:487–8.
Secomb, T. W., et al. “Analysis of oxygen transport to tumors: causes of heterogeneous tissue oxygenation.” American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, vol. 42, Dec. 1999, pp. 487–88.
Secomb TW, Hsu R, Braun RD, Dewhirst MW. Analysis of oxygen transport to tumors: causes of heterogeneous tissue oxygenation. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 1999 Dec 1;42:487–488.

Published In

American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

Publication Date

December 1, 1999

Volume

42

Start / End Page

487 / 488

Related Subject Headings

  • Biomedical Engineering