Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors.

Published

Journal Article

The extent of hypoxic regions in a tumor tissue depends on the arrangement, blood flow rate and blood oxygen content of microvessels, and on the tissue's oxygen consumption rate. Here, the effects of blood flow rate, blood oxygen content and oxygen consumption on hypoxic fraction are simulated theoretically, for a region whose microvascular geometry was derived from observations of a transplanted mammary andenocarcinoma (R3230AC) in a rat dorsal skin flap preparation. In the control state, arterial PO2 is 100 mmHg, consumption rate is 2.4 cm3 O2/100 g/min, and hypoxic fraction (tissue with PO2 < 3 mmHg) is 30%. Hypoxia is abolished by a reduction in consumption rate of at least 30%, relative to control, or an increase in flow rate by a factor of 4 or more, or an increase in arterial PO2 by a factor of 11 or more. These results suggest that reducing oxygen consumption rate may be more effective than elevating blood flow or oxygen content as a method to reduce tumor hypoxia.

Full Text

Duke Authors

Cited Authors

  • Secomb, TW; Hsu, R; Ong, ET; Gross, JF; Dewhirst, MW

Published Date

  • January 1995

Published In

Volume / Issue

  • 34 / 3

Start / End Page

  • 313 - 316

PubMed ID

  • 7779415

Pubmed Central ID

  • 7779415

Electronic International Standard Serial Number (EISSN)

  • 1651-226X

International Standard Serial Number (ISSN)

  • 0284-186X

Digital Object Identifier (DOI)

  • 10.3109/02841869509093981

Language

  • eng