Oxygen microelectrode measurements in R3230Ac tumors during photodynamic therapy with verteporfin


Journal Article

Measurements of tissue oxygen partial pressure (pO2), blood flow and blood pressure were recorded in rat mammary R3230Ac tumors during treatment with verteporfin-based photodynamic therapy. Microelectrodes of 12 micron tip diameter were used in a fixed position throughout the measurements to provide data on the temporal changes at a single location within the tissue. The microelectrode signal changes in pO2 indicated an overall trend to acute loss of pO2 after treatment, but with some notable exceptions where the pO2 did not decrease either during the treatment or after treatment. These regions which showed little change in pO2 were correlated with locations in which the pO2 was high to begin with before the initiation of treatment. Blood flow decreased during treatment, with the dominant effect immediately upon the initiation of treatment.

Full Text

Duke Authors

Cited Authors

  • Pogue, BW; Braun, RD; Lanzen, JL; Erickson, C; Dewhirst, MW

Published Date

  • January 1, 2001

Published In

Volume / Issue

  • 4248 /

Start / End Page

  • 144 - 149

International Standard Serial Number (ISSN)

  • 0277-786X

Digital Object Identifier (DOI)

  • 10.1117/12.424446

Citation Source

  • Scopus